Cellular response to oxygen-glucose deprivation

Across TCGA patient cohorts, RNA activity of the Cellular response to oxygen-glucose deprivation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD3, HSDL2, and RAB14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxygen-glucose deprivation activity versus BRD3 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BRD3 →	+0.246	+0.042	<.001	.001	3	6
CCRCC	HSDL2 →	+0.281	+0.052	<.001	<.001	3	5
CCRCC	RAB14 →	+0.273	+0.074	<.001	<.001	3	5
GBM	FUBP3 →	+0.151	+0.043	.001	.001	3	5
LSCC	MIGA2_S276 →	+0.409	+0.023	.001	.003	3	5
CCRCC	VPS13A →	+0.255	+0.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090650 vs BRD3 — GBM

Explore this scatter interactively →