Cellular response to oxygen-glucose deprivation

Across TCGA cell cohorts, RNA activity of the Cellular response to oxygen-glucose deprivation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, DIP2A, and RRM2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Cellular response to oxygen-glucose deprivation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MDM2 →	+2.201	+2.029	<.001	<.001	3	6
STOMACH	DIP2A →	+0.854	+1.470	.003	.004	3	5
STOMACH	RRM2B →	+1.404	+2.029	<.001	<.001	3	5
LARGE_INTESTINE	EPSTI1 →	-1.894	-1.323	<.001	<.001	3	4
LARGE_INTESTINE	ZSWIM7 →	+0.636	+0.985	.002	<.001	3	4
STOMACH	HERC5 →	-2.508	-1.758	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Cellular response to oxygen-glucose deprivation activity — STOMACH

Explore this box plot interactively →