Mitochondrial tRNA processing

Across TCGA cell cohorts, RNA activity of the Mitochondrial tRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX19, MPP1, and MRPS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX19 grouped by Mitochondrial tRNA processing-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SNX19 →	-1.104	-0.292	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MPP1 →	-1.623	-0.557	.001	.004	3	5
OESOPHAGUS	MRPS2 →	+1.030	+0.375	.007	<.001	3	4
SKIN	ZNF646 →	-0.415	-0.584	.003	.006	3	4
CNS	GOLGA8R →	-0.913	-0.874	<.001	.002	3	4
BREAST	SETD6 →	+0.852	+0.384	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX19 by Mitochondrial tRNA processing activity — BONE

Explore this box plot interactively →