Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

Across TCGA patient cohorts, RNA activity of the Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TERF2, DHX38, and EDC4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway activity versus TERF2 in GBM (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TERF2 →	+0.334	+0.045	<.001	<.001	3	7
OV	DHX38 →	+0.347	+0.056	<.001	<.001	3	7
BRCA	EDC4 →	+0.237	+0.049	<.001	<.001	3	7
LSCC	STK10 →	-0.408	-0.066	<.001	<.001	3	6
BRCA	PDF →	+0.466	+0.032	<.001	<.001	3	6
GBM	CKAP4_S26 →	-0.685	-0.085	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090611 vs TERF2 — GBM

Explore this scatter interactively →