Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

Across TCGA pan-cancer cohorts, RNA activity of the Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and KIRC, show the opposite pattern, with higher activity associated with better survival.

PAAD, UCEC, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Tertile	All	0.242	0.622	<.001	30	view →
UCEC	DFS	Tertile	IV	0.248	0.721	<.001	28	view →
LIHC	OS	Tertile	II,III,IV	0.517	0.782	.003	24	view →
READ	DFS	Tertile	II,III,IV	0.924	0.704	.011	23	view →
ESCA	OS	Median	All	0.377	1.000	.002	22	view →
KIRC	OS	Tertile	All	0.859	0.767	.012	21	view →
UVM	OS	Quartile	III,IV	0.070	0.859	.003	16	view →
SCLC	OS	Median	II,III,IV	0.421	1.000	.002	12	view →
LUAD	OS	Tertile	All	0.226	0.411	.007	12	view →
COAD	OS	Tertile	IV	0.834	0.331	.017	10	view →
THCA	DFS	Tertile	III,IV	0.842	0.968	.017	10	view →
STAD	OS	Median	IV	0.725	0.332	.022	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0090611–PAAD (DFS)

Open the PAAD breakdown →