Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS4B, VPS4A, and CHMP4C, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS4B grouped by Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VPS4B →	-0.392	-1.330	<.001	.007	3	8
BREAST	VPS4A →	-0.421	-1.273	.001	.002	3	6
SOFT_TISSUE	CHMP4C →	-0.430	-1.739	.004	.007	2	7
URINARY_TRACT	TTC28 →	-0.180	-0.393	<.001	.001	3	4
BREAST	FEM1A →	+0.135	+1.184	.008	.007	3	4
LIVER	SH2D3C →	+0.210	+0.846	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS4B by Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway activity — OVARY

Explore this box plot interactively →