Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA13, ARVCF, and SWAP70, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPATA13 grouped by Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPATA13 →	+1.878	+0.976	.002	.005	3	3
SKIN	ARVCF →	-0.802	-0.738	.006	.002	3	3
URINARY_TRACT	SWAP70 →	-1.343	-0.342	.005	.009	3	3
SOFT_TISSUE	MT-ND1 →	-1.670	-1.543	<.001	.008	3	3
LUNG_SCLC	PIM1 →	+1.505	+1.345	.008	.002	3	3
LUNG_SCLC	SPRY1 →	-1.874	-0.915	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPATA13 by Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway activity — LARGE_INTESTINE

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