Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPM, ZNF236, and VPS4A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway activity versus CENPM in BLOOD_Leukemia (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CENPM →	+0.890	+0.178	<.001	<.001	3	6
BLOOD_Leukemia	ZNF236 →	+0.719	+0.206	.004	.001	3	6
BREAST	VPS4A →	+0.620	+0.375	.002	.008	3	6
LUNG_SCLC	MARCKSL1 →	+1.605	+0.274	.002	<.001	3	6
SOFT_TISSUE	RNF126 →	+0.714	+0.383	.008	.003	2	7
BLOOD_Leukemia	KIAA0895L →	+1.173	+0.177	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090611 vs CENPM — BLOOD_Leukemia

Explore this scatter interactively →