Regulation of membrane permeability

Across TCGA cell cohorts, RNA activity of the Regulation of membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4, CGN, and CYB5D1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane permeability activity versus MAP4 in OVARY (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAP4 →	-0.898	-0.246	.001	<.001	3	7
OESOPHAGUS	CGN →	+1.828	+0.260	.002	.003	3	6
BONE	CYB5D1 →	-1.020	-0.242	.009	.003	3	6
BLOOD_Leukemia	LLGL1 →	-1.101	-0.153	.001	.004	3	6
BLOOD_Leukemia	ZNF18 →	-0.708	-0.163	<.001	<.001	3	6
LARGE_INTESTINE	CNTROB →	-0.787	-0.272	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090559 vs MAP4 — OVARY

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