Establishment of endothelial intestinal barrier

Across TCGA patient cohorts, RNA activity of the Establishment of endothelial intestinal barrier pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM144, C1orf210, and CTSZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of endothelial intestinal barrier activity versus TMEM144 in LUAD (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TMEM144 →	+0.570	+0.154	.001	.002	3	5
HNSC	C1orf210 →	+0.907	+1.076	<.001	<.001	3	5
HNSC	CTSZ →	-0.805	-0.807	<.001	<.001	3	5
GBM	AFDN →	+0.746	+0.770	<.001	<.001	3	5
UCEC	TMEM62 →	+0.539	+0.273	<.001	<.001	3	5
PDAC	CDS1 →	+0.678	+0.848	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090557 vs TMEM144 — LUAD

Explore this scatter interactively →