Establishment of endothelial intestinal barrier

Across TCGA pan-cancer cohorts, RNA activity of the Establishment of endothelial intestinal barrier pathway is associated with patient survival in 16 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Establishment of endothelial intestinal barrier pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

HNSC, LGG, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.810	0.603	.001	54	view →
LGG	OS	Median	All	0.320	0.532	<.001	53	view →
MESO	OS	Median	All	0.254	0.478	<.001	39	view →
SCLC	DFS	Tertile	II,III,IV	0.247	0.976	.017	25	view →
LUAD	OS	Median	II,III,IV	0.316	0.176	.015	21	view →
DLBC	DFS	Median	All	0.643	1.000	.021	9	view →
THYM	OS	Median	All	0.922	0.988	.032	8	view →
ESCA	DFS	Median	III,IV	0.440	0.239	.011	8	view →
UCEC	OS	Median	All	0.593	0.723	.041	6	view →
LUSC	OS	Tertile	II,III,IV	1.000	0.718	.019	6	view →
PCPG	OS	Tertile	All	0.807	1.000	.021	3	view →
THCA	DFS	Median	All	0.929	0.716	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

GO:0090557–HNSC (DFS)

Open the HNSC breakdown →