Establishment of endothelial intestinal barrier

Across TCGA cell cohorts, RNA activity of the Establishment of endothelial intestinal barrier pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMSAP3, TAF3, and MRPL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAMSAP3 grouped by Establishment of endothelial intestinal barrier-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CAMSAP3 →	-0.928	-0.988	.002	.002	3	4
SKIN	TAF3 →	+0.376	+0.836	.001	.006	3	4
LUNG_NSCLC_LUAD	MRPL3 →	-0.382	-0.540	.001	.005	3	3
LUNG_NSCLC_LUAD	RBM47 →	-1.845	-0.450	<.001	.003	3	3
LUNG_NSCLC_LUAD	MTARC1 →	-1.468	-0.492	.003	.002	3	3
STOMACH	AGAP4 →	-0.746	-1.145	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAMSAP3 by Establishment of endothelial intestinal barrier activity — SOFT_TISSUE

Explore this box plot interactively →