Establishment of endothelial intestinal barrier

Across TCGA cell cohorts, RNA activity of the Establishment of endothelial intestinal barrier pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR2L5, KIF2C, and ELMOD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR2L5 grouped by Establishment of endothelial intestinal barrier-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR2L5 →	-0.137	-1.279	.001	<.001	3	3
LIVER	KIF2C →	-0.266	-0.345	<.001	.003	3	3
LUNG_SCLC	ELMOD2 →	-0.143	-0.372	.002	.001	3	3
BLOOD_Leukemia	ALDH3B2 →	-0.226	-1.251	<.001	.002	3	3
KIDNEY	B3GNT4 →	+0.252	+0.414	.001	.001	2	4
BLOOD_Lymphoma	GABRB3 →	+0.360	+1.716	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR2L5 by Establishment of endothelial intestinal barrier activity — SKIN

Explore this box plot interactively →