Establishment of endothelial intestinal barrier

Across TCGA cell cohorts, RNA activity of the Establishment of endothelial intestinal barrier pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7, MYO6, and MYH14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of endothelial intestinal barrier activity versus MAP7 in LUNG_SCLC (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAP7 →	+1.899	+0.762	.002	.005	3	7
LUNG_SCLC	MYO6 →	+1.516	+0.517	.001	.009	3	7
LUNG_SCLC	MYH14 →	+2.825	+0.758	<.001	.006	3	7
LUNG_NSCLC_LUAD	PLEKHA7 →	+1.510	+0.443	<.001	.001	3	7
LUNG_NSCLC_LUAD	CLDN4 →	+3.122	+0.528	.001	.002	3	7
PANCREAS	MUC4 →	+5.314	+1.032	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090557 vs MAP7 — LUNG_SCLC

Explore this scatter interactively →