Vesicle tethering involved in exocytosis

Across TCGA patient cohorts, RNA activity of the Vesicle tethering involved in exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, RRBP1_T275, and MAP4_S696, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering involved in exocytosis activity versus RFC1_T506 in COAD (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RFC1_T506 →	-0.838	-0.034	<.001	<.001	3	6
GBM	RRBP1_T275 →	-0.781	-0.056	<.001	.006	2	7
CCRCC	MAP4_S696 →	-0.668	-0.066	<.001	<.001	3	6
BRCA	EXOC8 →	+0.219	+0.038	<.001	<.001	3	6
CCRCC	RRBP1_S615 →	-0.631	-0.056	<.001	<.001	3	6
PDAC	SLC16A3 →	-0.438	-0.043	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090522 vs RFC1_T506 — COAD

Explore this scatter interactively →