Vesicle tethering involved in exocytosis

Across TCGA pan-cancer cohorts, RNA activity of the Vesicle tethering involved in exocytosis pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Vesicle tethering involved in exocytosis pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and LGG, show the opposite pattern, with higher activity associated with better survival.

SCLC, LGG, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Tertile	II,III,IV	0.715	0.263	<.001	51	view →
LGG	OS	Median	All	0.538	0.338	<.001	42	view →
UVM	DFS	Median	III,IV	0.277	0.601	.011	36	view →
OV	OS	Quartile	All	0.301	0.447	.001	34	view →
BRCA	DFS	Quartile	III,IV	0.911	0.777	.004	33	view →
LIHC	OS	Quartile	All	0.606	0.815	<.001	32	view →
KIRC	DFS	Quartile	III,IV	0.554	0.331	.006	27	view →
ESCA	OS	Median	IV	0.143	0.650	.004	24	view →
CHOL	DFS	Quartile	All	0.107	0.503	.004	21	view →
READ	DFS	Median	II,III,IV	0.867	0.312	.002	20	view →
ACC	DFS	Median	III,IV	0.734	0.395	.008	19	view →
THYM	DFS	Median	II,III,IV	0.964	0.826	.007	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0090522–SCLC (DFS)

Open the SCLC breakdown →