Vesicle tethering involved in exocytosis

Across TCGA patient cohorts, RNA activity of the Vesicle tethering involved in exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF11, ELAPOR1, and SMCHD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering involved in exocytosis activity versus TAF11 in LSCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TAF11 →	-0.338	-0.158	.002	.001	3	5
BRCA	ELAPOR1 →	+1.719	+0.181	.001	.001	3	4
CCRCC	SMCHD1 →	-0.358	-0.189	<.001	.001	3	4
BRCA	RNGTT →	-0.489	-0.204	<.001	<.001	2	5
CCRCC	RARS2 →	-0.265	-0.161	.002	.003	3	4
CCRCC	HSF2 →	-0.280	-0.147	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090522 vs TAF11 — LSCC

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