Vesicle tethering involved in exocytosis

Across TCGA cell cohorts, RNA activity of the Vesicle tethering involved in exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2A, BCL7A, and RHOBTB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering involved in exocytosis activity versus UBE2A in LIVER (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	UBE2A →	+1.151	+0.459	.002	.008	3	5
BLOOD_Lymphoma	BCL7A →	-3.016	-0.252	.001	.004	3	5
BLOOD_Lymphoma	RHOBTB2 →	-1.587	-0.266	<.001	.001	3	4
LUNG_NSCLC_LUAD	CAB39 →	+0.960	+0.346	.004	.001	3	4
BREAST	UBE2H →	+0.798	+0.224	.006	.008	3	4
BREAST	CHPF2 →	+1.038	+0.370	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090522 vs UBE2A — LIVER

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