Podocyte cell migration

Across TCGA patient cohorts, RNA activity of the Podocyte cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, PACSIN2, and CACNA2D1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Podocyte cell migration activity versus SEPTIN4_S432 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4_S432 →	+1.089	+0.087	<.001	<.001	3	6
UCEC	PACSIN2 →	-0.296	-0.069	.001	<.001	3	6
GBM	CACNA2D1 →	+0.521	+0.046	.001	.008	3	5
CCRCC	PTK7 →	+0.324	+0.043	<.001	<.001	3	5
LSCC	KANK1 →	+0.376	+0.061	.001	<.001	3	5
UCEC	PBXIP1 →	+0.506	+0.052	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090521 vs SEPTIN4_S432 — GBM

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