Podocyte cell migration

Across TCGA cell cohorts, RNA activity of the Podocyte cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STRN4, GIMAP5, and XKR4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STRN4 grouped by Podocyte cell migration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	STRN4 →	-0.201	-0.950	.005	.002	3	4
OVARY	GIMAP5 →	+0.275	+1.295	.006	.007	3	4
LIVER	XKR4 →	-0.148	-1.216	.001	.005	3	3
LUNG_NSCLC_LUSC	HMCN1 →	-0.390	-1.628	.002	.001	3	3
LUNG_NSCLC_LUAD	PKN2 →	+0.207	+1.011	.002	.002	3	3
PANCREAS	PRPF4B →	-0.268	-1.139	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STRN4 by Podocyte cell migration activity — BREAST

Explore this box plot interactively →