Endocardial cushion to mesenchymal transition

pathway activity — cross-omics
GO:0090500Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Endocardial cushion to mesenchymal transition pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSF1_S1359, SCARF2_S698, and SDCCAG8_S92, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACRSF1_S1359 →-0.488-0.210.004.00232
PDACSCARF2_S698 →+1.295+0.463<.001<.00132
PDACSDCCAG8_S92 →+0.428+0.256<.001<.00123
GBMTBC1D10B_S28 →+0.931+0.398.003<.00132
PDACTWIST1_S68 →+0.686+0.210<.001<.00132
PDACWBP1L_S228 →+0.601+0.258<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration