Cellular senescence

Across TCGA cell cohorts, RNA activity of the Cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5orf34, BRPF1, and LEMD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C5orf34 grouped by Cellular senescence-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C5orf34 →	+1.033	+0.212	.002	.009	3	7
LUNG_NSCLC_LUSC	BRPF1 →	+0.858	+0.223	.002	.005	3	5
KIDNEY	LEMD2 →	+0.642	+1.431	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	TAP1 →	+2.084	+0.328	.001	.008	3	4
PANCREAS	CERS2 →	+0.727	+0.210	.006	.006	3	4
OESOPHAGUS	TMED4 →	+0.920	+0.232	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C5orf34 by Cellular senescence activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →