Cellular senescence

Across TCGA cell cohorts, RNA activity of the Cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, NDUFAF4, and CHAF1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular senescence activity versus ILF3 in BLOOD_Lymphoma (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ILF3 →	-0.740	-0.282	<.001	<.001	3	8
BLOOD_Lymphoma	NDUFAF4 →	-0.954	-0.165	<.001	.001	3	7
PANCREAS	CHAF1A →	-0.879	-0.268	.001	.001	3	7
LIVER	BOLA3 →	-0.482	-0.238	.005	<.001	3	7
BREAST	DHX9 →	-0.416	-0.182	.002	.001	3	6
STOMACH	RPL3 →	-0.867	-0.250	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090398 vs ILF3 — BLOOD_Lymphoma

Explore this scatter interactively →