Negative regulation of excitatory postsynaptic potential

Across TCGA cell cohorts, RNA activity of the Negative regulation of excitatory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PANK2, KTI12, and ZYG11B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PANK2 grouped by Negative regulation of excitatory postsynaptic potential-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PANK2 →	+0.686	+0.222	.003	.005	3	5
LARGE_INTESTINE	KTI12 →	+0.427	+0.142	.002	.006	2	6
LUNG_NSCLC_LUSC	ZYG11B →	+0.838	+0.218	.001	.005	3	5
URINARY_TRACT	ANKRD13C →	+0.809	+0.415	.003	<.001	3	4
URINARY_TRACT	CELF1 →	+1.050	+0.481	.006	<.001	3	4
URINARY_TRACT	ZNF408 →	+0.560	+0.303	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PANK2 by Negative regulation of excitatory postsynaptic potential activity — CNS

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