Phagosome acidification

Across TCGA patient cohorts, RNA activity of the Phagosome acidification pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCAT1, CASP8, and ANXA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome acidification activity versus BCAT1 in LUAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BCAT1 →	+0.519	+0.064	.006	<.001	3	5
LSCC	CASP8 →	+0.300	+0.076	<.001	<.001	3	5
COAD	ANXA2 →	+0.296	+0.042	.007	.008	2	6
BRCA	RAB38 →	+0.624	+0.063	<.001	<.001	3	5
LSCC	ATG7 →	+0.240	+0.077	<.001	<.001	3	5
LSCC	ISCA1 →	-0.500	-0.090	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090383 vs BCAT1 — LUAD

Explore this scatter interactively →