Phagosome acidification

Across TCGA patient cohorts, RNA activity of the Phagosome acidification pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAGLROS, SNCG, and MMRN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome acidification activity versus HAGLROS in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HAGLROS →	-0.663	-0.284	<.001	.004	3	3
UCEC	SNCG →	-0.872	-0.273	.002	.009	2	4
UCEC	MMRN2 →	-0.425	-0.288	.009	.001	3	3
UCEC	OR52Q1P →	-0.436	-0.284	.009	.005	3	3
UCEC	LBHD2 →	-0.289	-0.286	.002	.001	3	3
PDAC	DPYD-AS1 →	+0.597	+0.413	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090383 vs HAGLROS — LSCC

Explore this scatter interactively →