Phagosome acidification

Across TCGA cell cohorts, RNA activity of the Phagosome acidification pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRT2, DOLPP1, and ZBTB21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagosome acidification activity versus PRRT2 in BREAST (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRRT2 →	+1.350	+0.183	<.001	<.001	3	4
LUNG_SCLC	DOLPP1 →	-0.655	-0.131	.008	.005	3	4
KIDNEY	ZBTB21 →	-1.150	-0.126	.006	.005	3	3
BREAST	NAB2 →	+1.157	+0.140	<.001	.002	3	3
LUNG_NSCLC_LUSC	C20orf96 →	-1.869	-0.230	.001	<.001	3	3
LIVER	MAP3K12 →	+2.006	+0.229	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090383 vs PRRT2 — BREAST

Explore this scatter interactively →