Negative regulation of platelet aggregation

Across TCGA cell cohorts, RNA activity of the Negative regulation of platelet aggregation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITIH4, PIWIL4, and PRICKLE2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of platelet aggregation activity versus ITIH4 in LARGE_INTESTINE (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITIH4 →	+0.659	+0.198	.001	.007	2	5
CNS	PIWIL4 →	+0.608	+0.365	.004	<.001	3	4
SKIN	PRICKLE2 →	+1.261	+0.366	<.001	<.001	3	4
STOMACH	OXLD1 →	-1.033	-0.360	.002	.001	3	4
SKIN	ARL15 →	+0.595	+0.263	.002	.002	3	4
SKIN	TMEM17 →	+0.500	+0.242	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090331 vs ITIH4 — LARGE_INTESTINE

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