Regulation of platelet aggregation

Across TCGA patient cohorts, RNA activity of the Regulation of platelet aggregation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKCA_S226, PRKCQ_S695, and DCN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet aggregation activity versus PRKCA_S226 in PDAC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PRKCA_S226 →	+0.569	+0.173	<.001	<.001	3	6
PDAC	PRKCQ_S695 →	+0.643	+0.162	.001	.001	2	7
GBM	DCN →	+1.053	+0.309	<.001	<.001	3	6
LSCC	SYNPO2_T755 →	+0.784	+0.283	<.001	<.001	3	5
GBM	TARDBP →	-0.510	-0.308	<.001	<.001	3	5
LSCC	TRIM28_S697 →	-0.722	-0.162	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090330 vs PRKCA_S226 — PDAC

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