Regulation of platelet aggregation

Across TCGA cell cohorts, RNA activity of the Regulation of platelet aggregation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02693, NT5DC1, and TNNI2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet aggregation activity versus LINC02693 in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LINC02693 →	-1.622	-0.457	<.001	.003	3	5
LUNG_NSCLC_LUSC	NT5DC1 →	-1.460	-0.556	.001	.008	3	5
PANCREAS	TNNI2 →	+2.763	+0.351	.002	<.001	3	4
LUNG_NSCLC_LUAD	SCAMP2 →	+0.844	+0.550	<.001	.003	3	4
LARGE_INTESTINE	KLK6 →	+3.720	+0.562	.001	.007	3	4
OVARY	TCOF1 →	-0.805	-0.205	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090330 vs LINC02693 — BLOOD_Leukemia

Explore this scatter interactively →