Negative regulation of oxidative phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of oxidative phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSP90AB3P, RPL9P18, and RPS24P8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidative phosphorylation activity versus HSP90AB3P in CCRCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HSP90AB3P →	-0.397	-0.996	<.001	.001	3	3
BRCA	RPL9P18 →	-0.909	-0.121	.002	<.001	3	3
CCRCC	RPS24P8 →	-0.362	-0.905	.002	.001	3	3
BRCA	RNF7 →	-0.377	-0.139	.001	.005	3	3
LUAD	YWHAZP10 →	-0.346	-0.108	.001	.004	3	3
BRCA	ZC3H7B →	+0.478	+0.123	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090324 vs HSP90AB3P — CCRCC

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