Negative regulation of oxidative phosphorylation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of oxidative phosphorylation pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Negative regulation of oxidative phosphorylation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THCA and KIRP, show the opposite pattern, with higher activity associated with better survival.

SKCM, LUAD, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.236	0.424	<.001	48	view →
LUAD	DFS	Median	IV	0.260	0.741	.007	33	view →
THCA	DFS	Tertile	All	0.985	0.917	.002	32	view →
KIRC	DFS	Median	II,III,IV	0.413	0.593	.009	27	view →
KIRP	OS	Tertile	All	1.000	0.652	.014	25	view →
ESCA	OS	Quartile	II,III,IV	0.471	0.754	.004	25	view →
LAML	DFS	Quartile	All	0.539	0.286	.019	22	view →
UVM	DFS	Median	II,III,IV	0.765	0.454	.003	20	view →
BRCA	OS	Median	IV	0.326	0.832	.001	20	view →
MESO	OS	Quartile	All	0.716	0.458	.002	20	view →
LIHC	OS	Quartile	III,IV	0.695	0.313	.003	20	view →
ACC	OS	Tertile	IV	0.344	0.724	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0090324–SKCM (OS)

Open the SKCM breakdown →