Negative regulation of oxidative phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidative phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL27, PPIF, and MUC20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidative phosphorylation activity versus MRPL27 in BLOOD_Myeloma (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MRPL27 →	+1.293	+0.330	.002	.003	3	4
BLOOD_Lymphoma	PPIF →	+0.931	+0.238	.001	.002	3	4
LARGE_INTESTINE	MUC20 →	-3.647	-0.411	.003	.008	3	4
SOFT_TISSUE	SPTY2D1OS →	-0.621	-0.301	.002	.006	3	4
SKIN	ZBED1 →	+0.947	+0.290	.004	.004	3	3
BREAST	PRPF40B →	-0.719	-0.625	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090324 vs MRPL27 — BLOOD_Myeloma

Explore this scatter interactively →