Negative regulation of intracellular protein transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of intracellular protein transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRPEL1, MRPS35, and MRRF, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intracellular protein transport activity versus GRPEL1 in OV (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GRPEL1 →	-0.507	-0.035	<.001	<.001	3	8
LSCC	MRPS35 →	-0.335	-0.035	.001	.002	3	7
LSCC	MRRF →	-0.449	-0.036	<.001	<.001	3	7
OV	PRKG1 →	+0.831	+0.039	<.001	<.001	3	7
CCRCC	KANK2 →	+0.558	+0.031	<.001	.003	3	7
COAD	TTC7B →	+0.321	+0.028	.006	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090317 vs GRPEL1 — OV

Explore this scatter interactively →