Negative regulation of intracellular protein transport

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of intracellular protein transport pathway differs between tumor and matched normal tissue in 6 of the 18 cancer types tested.

The strongest signal is observed in cholangiocarcinoma (CHOL), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUSC and PRAD, show the opposite pattern, with lower activity in tumor tissue.

CHOL, LUSC, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
CHOL	All	All	+0.063	<.001	5	view →
LUSC	All	III,IV	−0.050	.004	4	view →
KIRP	All	II,III,IV	+0.024	.020	4	view →
LIHC	All	All	+0.010	.014	3	view →
UCEC	All	IV	+0.049	.019	2	view →
PRAD	All	All	−0.017	.003	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 6 strongest of 6 lineages.

GO:0090317–CHOL

Open the CHOL breakdown →