Positive regulation of intracellular protein transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of intracellular protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP1, MON1A, and UPK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intracellular protein transport activity versus THAP1 in BLOOD_Lymphoma (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	THAP1 →	-0.672	-0.133	<.001	<.001	3	5
SKIN	MON1A →	-0.534	-0.114	.006	.008	3	5
URINARY_TRACT	UPK2 →	+4.502	+0.226	<.001	.001	3	5
URINARY_TRACT	LRRC6 →	-1.924	-0.356	.001	.004	2	6
SKIN	NR2F6 →	-0.708	-0.200	<.001	<.001	3	4
CNS	ANXA2 →	+1.190	+0.075	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090316 vs THAP1 — BLOOD_Lymphoma

Explore this scatter interactively →