Negative regulation of protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein targeting to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DMTN_S16, FCER1G, and CRTAP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein targeting to membrane activity versus DMTN_S16 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DMTN_S16 →	+0.668	+0.056	<.001	.002	3	6
COAD	FCER1G →	-0.595	-0.028	<.001	.006	3	6
BRCA	CRTAP →	-0.518	-0.053	<.001	.004	3	5
LSCC	THEMIS2_T593 →	-0.535	-0.077	.002	.001	3	5
GBM	FERMT3 →	-0.542	-0.106	<.001	<.001	3	5
GBM	SPTAN1 →	+0.446	+0.133	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090315 vs DMTN_S16 — BRCA

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