Negative regulation of protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSTYK, IER3, and VPS13B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DSTYK grouped by Negative regulation of protein targeting to membrane-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DSTYK →	-0.394	-0.898	.008	<.001	3	4
LUNG_SCLC	IER3 →	+2.400	+1.298	.007	<.001	3	4
KIDNEY	VPS13B →	-0.725	-1.474	.002	<.001	3	4
KIDNEY	PRR14L →	-0.916	-1.519	<.001	<.001	3	4
LIVER	CFAP157 →	-0.559	-2.125	.004	.001	3	4
LUNG_SCLC	HAS3 →	-1.171	-1.373	.008	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DSTYK by Negative regulation of protein targeting to membrane activity — BREAST

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