Positive regulation of protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPYSL3, ACCS, and KLC1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPYSL3 grouped by Positive regulation of protein targeting to membrane-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DPYSL3 →	-2.161	-1.383	.003	<.001	3	3
LIVER	ACCS →	-2.639	-0.418	<.001	.006	3	3
SOFT_TISSUE	KLC1 →	-1.155	-1.082	.002	.001	3	3
STOMACH	C12orf60 →	+0.501	+0.644	.001	.003	3	3
SOFT_TISSUE	KATNAL1 →	-0.967	-0.864	.002	<.001	3	3
SOFT_TISSUE	CPD →	-0.674	-1.026	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPYSL3 by Positive regulation of protein targeting to membrane activity — BONE

Explore this box plot interactively →