Positive regulation of DNA methylation-dependent heterochromatin formation
pathway activity — cross-omics
GO:0090309Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts
Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA methylation-dependent heterochromatin formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.
The most reproducible pathway-associated genes across cancer lineages are TMPO, ESPL1, and KNTC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.
Pathway-associated genes by consensus
Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.