Mitotic spindle assembly

Across TCGA patient cohorts, RNA activity of the Mitotic spindle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, TOP2A, and NCAPD2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic spindle assembly activity versus RPL12_S38 in LUAD (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.270	+0.113	<.001	<.001	3	10
LUAD	TOP2A →	+1.320	+0.136	<.001	<.001	3	10
LUAD	NCAPD2 →	+0.867	+0.123	<.001	<.001	3	10
LUAD	TOP2A_S1247 →	+1.702	+0.125	<.001	<.001	3	10
LUAD	HAT1 →	+0.471	+0.096	<.001	<.001	3	10
GBM	RFC2 →	+0.618	+0.081	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090307 vs RPL12_S38 — LUAD

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