Meiotic spindle assembly

Across TCGA patient cohorts, RNA activity of the Meiotic spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM72A, FBXO5, and LMNB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic spindle assembly activity versus FAM72A in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM72A →	+0.602	+0.224	<.001	.001	3	4
BRCA	FBXO5 →	+0.839	+0.309	<.001	<.001	3	3
UCEC	LMNB1 →	+0.909	+0.591	<.001	.001	3	3
LSCC	CIT →	+0.472	+0.198	<.001	.001	3	3
BRCA	CDC25C →	+0.637	+0.196	.003	.004	3	3
UCEC	KNTC1 →	+0.612	+0.823	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090306 vs FAM72A — BRCA

Explore this scatter interactively →