Obsolete nucleic acid phosphodiester bond hydrolysis
associated omics data
GO:0090305Ontology (GO BP)GO biological process · ~25 member genes
Q-omics provides the Obsolete nucleic acid phosphodiester bond hydrolysis (GO:0090305) pathway profile, scoring each patient from the combined activity of its roughly 25 member genes. Pathway activity is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 9, with the highest sampling consensus in KIRC. Additionally, pathway RNA activity shows 36,491 significant cross-omics associations, again with the highest sampling consensus in HNSC. Together, these results highlight UCS, KIRC, and HNSC as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Obsolete nucleic acid phosphodiester bond hydrolysis survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Obsolete nucleic acid phosphodiester bond hydrolysis activity shows favorable associations in UCS, READ, LUAD and BLCA, but unfavorable associations in LGG and COAD. In the UCS Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p = .002). UCS ranks highest by sampling consensus for Obsolete nucleic acid phosphodiester bond hydrolysis.
This table summarizes Obsolete nucleic acid phosphodiester bond hydrolysis tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 9 cancer types. The strongest signals are in KIRC for RNA.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across THCA, BLCA, CHOL and STAD and lower tumor activity in KIRC and KIRP. In the KIRC box plot, normal samples show higher pathway activity than tumor samples (log2 FC = −0.084, t-test p < 0.001).
This table shows molecular features associated with Obsolete nucleic acid phosphodiester bond hydrolysis pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in HNSC. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in PANCREAS.