Regulation of osteoclast proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of osteoclast proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL6A2, FAP, and ITGA5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoclast proliferation activity versus COL6A2 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL6A2 →	+0.895	+0.173	<.001	<.001	3	7
COAD	FAP →	+0.710	+0.065	.001	<.001	3	7
GBM	ITGA5 →	+0.576	+0.161	<.001	<.001	3	7
GBM	ITGB1 →	+0.498	+0.195	<.001	<.001	3	7
COAD	RRAS →	+0.389	+0.058	<.001	<.001	3	7
COAD	ACTN1 →	+0.475	+0.076	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090289 vs COL6A2 — GBM

Explore this scatter interactively →