Regulation of osteoclast proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of osteoclast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS12, COL3A1, and ADAMTS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoclast proliferation activity versus ADAMTS12 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADAMTS12 →	+0.795	+0.466	<.001	<.001	3	5
BRCA	COL3A1 →	+1.293	+0.606	<.001	.001	3	5
BRCA	ADAMTS2 →	+1.095	+0.691	<.001	.002	3	5
BRCA	ADAM12 →	+1.294	+0.577	<.001	.002	3	5
BRCA	COL1A2 →	+0.822	+0.468	.003	.001	3	5
GBM	SERPINE1 →	+1.100	+0.385	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090289 vs ADAMTS12 — LSCC

Explore this scatter interactively →