Regulation of osteoclast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoclast proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GREM1, PTH, and TUBG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GREM1 grouped by Regulation of osteoclast proliferation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GREM1 →	-0.292	-0.885	<.001	<.001	3	8
BREAST	PTH →	-0.291	-0.968	<.001	<.001	3	6
SKIN	TUBG1 →	+0.269	+0.773	.005	.003	3	5
KIDNEY	LCE5A →	+0.298	+2.091	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ZNF257 →	+0.441	+0.364	<.001	.004	3	4
PANCREAS	STK26 →	+0.303	+1.440	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GREM1 by Regulation of osteoclast proliferation activity — CNS

Explore this box plot interactively →