Regulation of osteoclast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoclast proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS53, COX4I1, and MPHOSPH6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS53 grouped by Regulation of osteoclast proliferation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	VPS53 →	-0.172	-1.022	.001	<.001	3	4
BREAST	COX4I1 →	-0.191	-0.706	.003	.005	3	4
BREAST	MPHOSPH6 →	+0.449	+1.210	.001	<.001	3	4
CNS	COL4A6 →	+0.198	+1.107	.002	<.001	3	4
LARGE_INTESTINE	AQR →	-0.285	-1.389	.006	.001	3	3
OESOPHAGUS	TTC22 →	+0.140	+1.347	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS53 by Regulation of osteoclast proliferation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →