Regulation of osteoclast proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of osteoclast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, IL32, and NMB, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoclast proliferation activity versus TNFAIP3 in URINARY_TRACT (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TNFAIP3 →	+2.577	+1.228	<.001	<.001	3	15
BREAST	IL32 →	+3.169	+1.119	<.001	<.001	3	10
LUNG_NSCLC_LUSC	NMB →	+2.588	+1.060	.002	.009	1	11
OVARY	BIRC3 →	+2.599	+0.772	<.001	.001	3	9
BLOOD_Lymphoma	NFKB2 →	+1.124	+0.091	.001	.009	3	9
BREAST	ICAM1 →	+2.053	+1.035	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090289 vs TNFAIP3 — URINARY_TRACT

Explore this scatter interactively →