Positive regulation of calcium ion import

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF44, KHDC4, and CLDN15, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion import activity versus RNF44 in BONE (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNF44 →	-1.651	-0.265	.001	.006	3	12
LARGE_INTESTINE	KHDC4 →	-0.886	-0.120	.001	<.001	3	12
KIDNEY	CLDN15 →	-1.391	-0.185	.003	<.001	3	11
BONE	FAM186B →	-0.471	-0.268	.004	.005	3	11
LUNG_NSCLC_LUSC	TMSB10 →	+1.272	+0.162	.003	<.001	3	11
SOFT_TISSUE	TMCO6 →	-1.347	-0.194	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090280 vs RNF44 — BONE

Explore this scatter interactively →