Positive regulation of calcium ion import

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBWD1, TIMP3, and TNFRSF14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion import activity versus CBWD1 in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CBWD1 →	+1.827	+0.970	.007	.009	2	5
PANCREAS	TIMP3 →	-3.947	-0.209	.004	<.001	3	3
OESOPHAGUS	TNFRSF14 →	+2.084	+0.242	<.001	.001	3	3
KIDNEY	ACVR1B →	-0.697	-0.352	.004	.005	2	4
SOFT_TISSUE	SRGAP3 →	+0.720	+0.390	.005	.005	3	3
OESOPHAGUS	DAPK2 →	+1.010	+0.296	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090280 vs CBWD1 — BLOOD_Leukemia

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